Polona Flerin graduated from the Faculty of Economics in Ljubljana.
She began her career in 1995 at a company Rotomatika. She then spent several years working for Nova Ljubljanska banka. From 2013 to 2018 she was the head of the Governor's Office at the Bank of Slovenia. Between 2018 and 2019 she was working at UniCredit Bank Slovenia, and from July 2019 to May 2020 at the Single Resolution Board in Brussels.